I may have entered Argentina by plane, but my departure via the scenic bus ride from Mendoza to Santiago (Chile) was worth the extra transit time.
In Mendoza, I bought my bus ticket from Andesmar a few days in advance for just $36.
By comparison, flights cost several hundred dollars, and you miss some of the most beautiful landscapes outside of Patagonia.

The bus ride from Mendoza to Santiago lasted about seven hours, including the time it took to pass through Argentina and Chilean Immigration.
The highway passes by Puenta del Inca, but this natural geologic bridge can't be viewed from the bus. My photo in this article was taken a few days earlier on a separate tour.
Another point of interest you can see from the bus if only for a few seconds, is Aconcagua, South America's tallest mountain at 22,837 feet (6,960 meters).
I lucked out in that it was a beautiful, clear day. Thanks to the GPS on my iPhone, I snapped a photo of the cloud-shrouded peak as we passed it by.

Michelle says
Wow love these pictures!
Dave says
Glad you enjoyed them Michelle!
Willy says
Beautiful photos Dave. I am familiar with that landscape because I did the same trip on horse when I was a 19-year-old veterinary student (now I am 80!) I allow myself to correct a mistake,: Neruda was a Nobel Prize winner not Pulitzer's..Sincerely Willy
Dave says
Wow, that must've been quite a ride!
Thanks for the correction about Neruda too. I'll fix that reference in the Santiago article.
Andi of My Beautiful Adventures says
Absolutely gorgeous! I would have been yelling at the bus driver to stop every five feet so that I could take a picture haha.
Sam says
Wow! Just looking at these pictures makes me feel dizzy! I guess in winter the landscape must look completely different. Out of this world!
Virgil says
Those pictures are sooo cool especially the one with all the turns. Glad you were in a modern looking bus!
mady rimbaud says
Hello,
your pictures are incredible. I wonder if there is a problem on this road when you have altitude sickness ?
do you feel it in the bus ?
Dave says
Thanks Mady. No, I didn't feel the altitude in the bus. Normally, a higher altitude is something you run into when when you're exerting yourself physically, like walking or climbing up steps. Then you might feel a little out of breath. But sitting on the bus, you won't feel any different.
Andrea Verhulst says
Were you on the left or the right side of the bus ? ;-)
Dave says
The bus wasn't full, so I was able to take photos out of both sides. Puenta del Inca cannot be seen from the highway (if I recall). I had gone there separately on a day trip before the bus ride.
Beth says
Hey Dave,
Great photos! Those hairpin turns look a little daunting. When did you take the bus from Mendoza to Santiago, April 2013? What was the immigration check point process like? Getting of the bus, luggage check, document check, etc? Did you have to pay the Chile's reciprocity fee or is that only at the airport? Any information you have would be great! Thanks
Dave says
Hi Beth, thanks for reading. I took the bus May 20, 2012 and don't recall having to pay anything upon entering Chile. The border process was quick and easy. Disembark, all luggage has to pass through a security check, get stamped out of Argentina, and stamped into Chile.
I left Chile a few weeks later via a tour through the Bolivian salt flats, and didn't have to pay anything on exit that I recall. It may only be you need to pay if you fly in/out versus crossing by land.
Beth says
Great, thanks for the information Dave!
Matthew says
Great article. Biplane on doing this route soon. What are the buses like? Facilities? Stops etc?
Alicia says
Beautiful! Thank you for sharing the amazing photos. I'm very excited to experience the hairpins myself in 3 months!
Norbert says
Hi Dave
just check your info regarding the bus rip from Santiago to Mendoza.
Does the bus stop at any other point than at the border?
I want to catch the impressions not only by riding on the bus and would appriciate if you can breath the air up in the mountains
Thanks in advance for feedback
Norbert
Dave says
Hi Norbert,
No, the bus I took on this route did not stop aside from the border. It's for transport, not tourism.
For this reason, I took a day tour beforehand from Mendoza which drove the same highway until the border. You need to do this if you want to see the Inca Bridge (which I recommend) as it's not directly along the highway. On the tour, we also stopped along the highway to get a glimpse of Aconcagua.
Pauline says
Can you please tell me what this pass is called and if we would have altitude sickness problems?
We are traveling from Brazil so would we stop a night in Mandoza or travel from Buenos Aries?
Dave says
I'm not sure what the pass is called, but it's unlikely you'll experience altitude sickness because you'll be traveling by bus and won't be at the higher altitudes for very long.
Pauline says
Thanks for your reply. Is there any other advice you can pass on re this bus trip. Would you fly from Buenos Aries into Mendosa? We are traveling from near Sao Paulo Brazil and heading to Santiago Chilie. We didn't want to fly all the way so were looking for a different route. Thanks
Dave says
I traveled via bus from Buenos Aires > Rosario > Cordoba > Mendoza > Santiago and enjoyed it.
Well, there wasn't much to see in Rosario so I could've skipped that city, but I liked spending a few days in Cordoba and and Mendoza on my way to Santiago.
The scenery between Buenos Aires and Mendoza was nothing special.
Sona says
Hi Dave,
Thank you for a great post!
Slightly strange but practical question -- Can you let me know if there are any toilet break stops along the way!
Also, do the windows open on the coach?
:) Thanks
Dave says
The only break I recall was when we were crossing the border. I believe snacks were served on the bus, and it was equipped with a bathroom, but I can't recall 100% for sure.
Linda says
We are thinking of doing the same route but the opposite direction, Santiago to Mendoza. Just curious, if there are no breaks other than the border crossing, is there a change of driver somewhere along the route? This trip is currently showing as 11.5 hours online, so rather a long haul for one driver.
ann says
Hi Dave! Would you know how the road is during winter? I've read somewhere that the roads partially close or something during winter. We will be doing a South America trip (Peru, Bolivia, Chile and Argentina) next month (July) and was also thinking about doing your Mendoza - Cordoba - Buenos Aires route. :)
Dave says
I think the pass may be closed in Winter due to the amount of snow they get. It'd be quite dangerous. You'd probably have to fly.
Matthew says
You can make the trip in the winter, although the road is often closed due to snow. If you have time to wait a day or 2 the bus is a good option. If not your only other option is an expensive plane ride.
Sheila Pye says
Hi,
I'm planning to catch the bus from Santiago to Mendoza in November and on the return journey, need to be back in Santiago by Friday, 25th November to catch the flight home. I have been told that the bus schedule isn't published until 4-6 weeks before departure. Do you know if generally there are buses on this route every day and are there any overnight buses?
Many thanks
Dave says
I don't know.
STEPHEN CHEUNG says
Hi, I shall be in Medellin between Dec. 16, and leaving at 19. Any tips for Medellin. After Medellin, I shall travel south to Brazil, Uruguay, Argentina, and last to Chile before flying back to Toronto. Your advice will be greatly appreciated. Stephen